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A Clinician’s Guide to Optical Genome Mapping (OGM) – a Revolution in Acute Leukemia Diagnosis

October 16 @ 7:00 pm - 8:00 pm EDT

Presentation and Discussion

When: Monday, October 16, 2023 at 7:00 PM EST

Where: Zoom – link will be provided upon registration

Faculty :

  • Adam C. Smith, MSc, PhD, FCCMG, FACMG, erCLG
  • Director, Cancer Cytogenetics Laboratory
  • University Health Network
  • Assistant Professor
  • Department of Laboratory Medicine and Pathobiology
  • University of Toronto


  1. What is Optical Genome Mapping (OGM)?
  2. What are the advantages and limitations of OGM compared to conventional cytogenetic
    approaches (e.g. Karyotype/FISH)?
  3. How are OGM data analyzed and reported?


Optical Genome Mapping is a new genome-wide, high-resolution assay for structural, chromosomal variation (i.e. structural and numeric changes). Its use is growing in Canada and around the world, especially in hematologic malignancies. With the higher resolution offered by OGM, we will see improved genetic classification for patients, and likely also an increase in novel observations.

Some of the questions we will discuss are:

  1. What will OGM reports look like, how do I interpret them?
  2. What types of novel abnormalities are we likely to see in OGM data?
  3. Why would we use OGM instead of another technology, e.g. genome sequencing.


October 16
7:00 pm - 8:00 pm EDT

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